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Image Search Results
Journal: Proceedings of the National Academy of Sciences of the United States of America
Article Title: Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice
doi: 10.1073/pnas.0711119105
Figure Lengend Snippet: Low doses of osteocalcin increase insulin secretion and β cell proliferation in WT mice. Analyses were performed in mice implanted with osmotic pumps infusing the indicated doses of osteocalcin (Ocn) or vehicle for 14 days (A) and 28 days (A–E). (A) Blood glucose (random feeding). (B) Serum insulin. (C) GSIS. (D) GTT. (E) Quantification of Ki67 immunoreactive cells in pancreatic islets. Results are mean values ± SEM. *, P < 0.05; **, P < 0.01 (Ocn vs. vehicle, Student's t test). a, P < 0.05 (Ocn 0.3 ng/h vs. vehicle); b, P < 0.05 (ANOVA) (Ocn 3 ng/h vs. vehicle). Six to 20 mice per group were analyzed.
Article Snippet: Sections were immunostained with a
Techniques: